PFOS facilitates liver inflammation and steatosis: An involvement of NLRP3 inflammasome‐mediated hepatocyte pyroptosis

Yi Qin; Tianye Gu; Junyi LingJiashan LuoJianya ZhaoBaoying HuLu HuaChunhua WanShengyang Jiang

首页> 外文期刊>Journal of applied toxicology >PFOS facilitates liver inflammation and steatosis: An involvement of NLRP3 inflammasome‐mediated hepatocyte pyroptosis

【24h】

PFOS facilitates liver inflammation and steatosis: An involvement of NLRP3 inflammasome‐mediated hepatocyte pyroptosis

机译：PFOS facilitates liver inflammation and steatosis: An involvement of NLRP3 inflammasome‐mediated hepatocyte pyroptosis

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Abstract Perfluorooctane sulfonate (PFOS) is a fluorinated organic pollutant with substantial accumulation in mammalian liver tissues. However, the impact of chronic PFOS exposure on liver disease progression and the underlying molecular mechanisms remain elusive. Herein, we for the first time revealed that micromolar range of PFOS exposure initiates the activation of NLR pyrin domain containing 3 (NLRP3) inflammasome to drive hepatocyte pyroptosis. We showed that 5?mg/kg/day PFOS exposure may exacerbated liver inflammation and steatosis in high‐fat diet (HFD)‐fed mice with concurrently elevated expression of NLRP3 and caspase‐1. PFOS exposure resulted in viability impairment and LDH release in BRL‐3A rat liver cells. 25–100?μM concentrations of PFOS exposure activated the NLRP3 inflammasome, leading to consequent GSDMD cleavage, IL‐1β release and the initiation of pyroptosis in a dose‐dependent manner, whereas treatment with 10?μM NLRP3 inhibitor MCC950 abrogated this effect. Moreover, pretreatment of 5?mM ROS scavenger N‐acetyl‐L‐cysteine (NAC) ameliorated PFOS‐induced NLRP3 inflammasome activation and pyroptosis. Collectively, our data highlight a pivotal role of pyroptotic death in PFOS‐mediated liver inflammation and metabolic disorder.

著录项

来源
《Journal of applied toxicology》 |2022年第6期|806-817|共12页
作者
Yi Qin; Tianye Gu; Junyi LingJiashan LuoJianya ZhaoBaoying HuLu HuaChunhua WanShengyang Jiang;
展开▼
作者单位

Department of Occupational Medicine and Environmental Toxicology, School of Public Health,Nantong;

Department of Nutrition and Food Hygiene, School of Public Health,Nantong University;

Department of Immunology, School of Medicine,Nantong UniversityDepartment of Oncology,Taizhou People's Hospital;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类毒物学（毒理学）;
关键词
hepatotoxicity; inflammation; NLRP3 inflammasome; PFOS; pyroptosis; ROS;

PFOS facilitates liver inflammation and steatosis: An involvement of NLRP3 inflammasome‐mediated hepatocyte pyroptosis

摘要

著录项

相关主题

期刊订阅