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首页> 外文期刊>Journal of cardiac surgery. >Novel hybrid total artificial heart with integrated oxygenator
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Novel hybrid total artificial heart with integrated oxygenator

机译：Novel hybrid total artificial heart with integrated oxygenator

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Abstract There continues to be an unmet therapeutic need for an alternative treatment strategy for respiratory distress and lung disease. We are developing a portable cardiopulmonary support system that integrates an implantable oxygenator with a hybrid, dual‐support, continuous‐flow total artificial heart (TAH). The TAH has a centrifugal flow pump that is rotating about an axial flow pump. By attaching the hollow fiber bundle of the oxygenator to the base of the TAH, we establish a new cardiopulmonary support technology that permits a patient to be ambulatory during usage. In this study, we investigated the design and improvement of the blood flow pathway from the inflow‐to‐outflow of four oxygenators using a mathematical model and computational fluid dynamics (CFD). Pressure loss and gas transport through diffusion were examined to assess oxygenator design. The oxygenator designs led to a resistance‐driven pressure loss range of less than 35?mmHg for flow rates of 1–7?L/min. All of the designs met requirements. The configuration having an outside‐to‐inside blood flow direction was found to have higher oxygen transport. Based on this advantageous flow direction, two designs (Model 1 and 3) were then integrated with the axial‐flow impeller of the TAH for simulation. Flow rates of 1–7?L/min and speeds of 10,000–16,000 RPM were analyzed. Blood damage studies were performed, and Model 1 demonstrated the lowest potential for hemolysis. Future work will focus on developing and testing a physical prototype for integration into the new cardiopulmonary assist system.

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