From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators

Hui Han; Bao Yi; Ruqing ZhongMengyu WangShunfen ZhangJie MaYulong YinJie YinLiang ChenHongfu Zhang

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From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators

机译：From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators

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Feelings of hunger and satiety are the key determinants for maintaining the life of humans and animals. Disturbed appetite control may disrupt the metabolic health of the host and cause various metabolic disorders. A variety of factors have been implicated in appetite control, including gut microbiota, which develop the intricate interactions to manipulate the metabolic requirements and hedonic feelings. Gut microbial metabolites and components act as appetite-related signaling molecules to regulate appetite-related hormone secretion and the immune system, or act directly on hypothalamic neurons. Herein, we summarize the effects of gut microbiota on host appetite and consider the potential molecular mechanisms. Furthermore, we propose that the manipulation of gut microbiota represents a clinical therapeutic potential for lessening the development and consequence of appetite-related disorders. Video abstract.

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来源
《microbiome》 |2021年第1期|162-177|共16页
作者
Hui Han; Bao Yi; Ruqing ZhongMengyu WangShunfen ZhangJie MaYulong YinJie YinLiang ChenHongfu Zhang;
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作者单位

State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences;

Precision Livestock and Nutrition Unit, Gembloux Agro-Bio Tech, University of Liège;

College of Animal Science and Technology, Hunan Agricultural UniversityKey Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences;

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正文语种英语
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关键词
Appetite; Gut microbiota; Hormone; Immune; Metabolites;

From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators

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