Carnitine derivatives beyond fatigue: an update

MicheleMalaguarnera; Vito EmanueleCatania; MarianoMalaguarnera

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Carnitine derivatives beyond fatigue: an update

机译：Carnitine derivatives beyond fatigue: an update

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Carnitine is an essential micronutrient that transfer long-chain fatty acids from the cytoplasm into the mitochondrial matrix for the β-oxidation. Carnitine is also needed for the mitochondrial efflux of acyl groups in the cases wherein substrate oxidation exceeds energy demands. Carnitine deficiency can affect the oxidation of free fatty acids in the mitochondria resulting in the aggregation of lipids in the cytoplasm instead of entering the citric acid cycle. The aggregation leads a lack of energy, acetyl coenzyme A accumulation in the mitochondria and cytotoxic production. Carnitine and its derivatives show great clinical therapeutic effect without significant side effects.

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《Current opinion in gastroenterology》 |2023年第2期|125-128|共4页
作者
MicheleMalaguarnera; Vito EmanueleCatania; MarianoMalaguarnera;
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作者单位

Universidad Europea de Valencia, Faculty of Health Science, Valencia, Spain;

Department of Medical, Surgical Sciences and Advanced Technologies ‘G.F. Ingrassia’;

Research Centre ‘The Great Senescence’, University of Catania, Catania, Italy;

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正文语种英语
中图分类消化系及腹部疾病;
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Carnitine derivatives beyond fatigue: an update

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