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首页> 外文期刊>iranian journal of microbiology >First report of SPM metallo-beta-lactamases producing Acinetobacter baumannii isolates in Morocco
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First report of SPM metallo-beta-lactamases producing Acinetobacter baumannii isolates in Morocco

机译：First report of SPM metallo-beta-lactamases producing Acinetobacter baumannii isolates in Morocco

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Background and Objectives: Carbapenem-resistant Acinetobacter baumannii has recently been identified by the World Health Organization as a critical pathogen. We propose to characterize the molecular characteristics of clinical isolates of A. baumannii resistant to carbapenems collected in a Moroccan hospital. Materials and Methods: Seventy carbapenem-resistant A. baumannii isolates from various samples were received at the microbiology laboratory of the Hospital Center. Antibiotic susceptibility was tested by the diffusion disc method and molecular characterization of antimicrobial resistance was performed by PCR and sequencing. Results: Carbapenemase genes were detected in our isolates: the OXA-51 gene and the ISbA1 sequence were detected in all isolates (100), the OXA-23 and OXA-58 genes were detected in 82.85 and 10 of isolates respectively, MBL genes were dominated by VIM 39 isolates (55.7), followed by GIM 26 isolates (37), SIM 20 isolates (28.5), IMP 8 isolates (11, 4), NDM 3 isolates (4) and for the first time in Morocco SPM with 4 isolates (5.7). Conclusion: The emergence of resistance of A. baumannii to carbapenems is a serious problem in our hospital which requires the establishment of a prevention strategy and strict respect for hygiene to minimize their dissemination.

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