Lysosome function in glomerular health and disease

Meyer-Schwesinger Catherine

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Lysosome function in glomerular health and disease

机译：Lysosome function in glomerular health and disease

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摘要

The lysosome represents an important regulatory platform within numerous vesicle trafficking pathways including the endocytic, phagocytic, and autophagic pathways. Its ability to fuse with endosomes, phagosomes, and autophagosomes enables the lysosome to break down a wide range of both endogenous and exogenous cargo, including macromolecules, certain pathogens, and old or damaged organelles. Due to its center position in an intricate network of trafficking events, the lysosome has emerged as a central signaling node for sensing and orchestrating the cells metabolism and immune response, for inter-organelle and inter-cellular signaling and in membrane repair. This review highlights the current knowledge of general lysosome function and discusses these findings in their implication for renal glomerular cell types in health and disease including the involvement of glomerular cells in lysosomal storage diseases and the role of lysosomes in nongenetic glomerular injuries.

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《Cell and Tissue Research》 |2021年第2期|371-392|共22页
作者
Meyer-Schwesinger Catherine;
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作者单位

Univ Med Ctr Hamburg Eppendorf, Inst Cellular & Integrat Physiol, Hamburg, Germany;

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原文格式 PDF
正文语种英语
中图分类细胞生物学;
关键词
Lysosome; Lysosomal storage disorder; Podocyte; Mesangial cell; Glomerulus; Glomerular endothelial cell; Membranous nephropathy; Focal segmental glomerulosclerosis; Crescentic glomerulonephritis; Diabetic nephropathy;

Lysosome function in glomerular health and disease

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