Nomogram based on MRI for preoperative prediction of Ki-67 expression in patients with intrahepatic mass cholangiocarcinoma

Chen Xiang; Zhu Jingfen; Zou ZiguiDu MingzhanXie JunjianYe YujieZhang LingLi Yonggang

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Nomogram based on MRI for preoperative prediction of Ki-67 expression in patients with intrahepatic mass cholangiocarcinoma

机译：Nomogram based on MRI for preoperative prediction of Ki-67 expression in patients with intrahepatic mass cholangiocarcinoma

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Objectives To validate a new nomogram based on magnetic resonance imaging (MRI) for pre-operative prediction of Ki-67 expression in patients with intrahepatic mass cholangiocarcinoma (IMCC). Methods A total of 78 patients with clinicopathologically confirmed IMCC who underwent pre-operative gadoliniumethoxybenzyl-diethylenetriamine pentaacetic acid enhanced MRI between 2016 and 2022 were enrolled in the training and validation group (53 patients and 25 patients, respectively). Images including qualitative, quantitative MRI features and clinical data were evaluated. Univariate analysis and multivariate logistic regression were used to select the independent predictors and establish different predictive models. The predictive performance was validated by operating characteristic curve (ROC) analysis, calibration curve, and decision curve analysis (DCA). The validation cohort was used to test the predictive performance of the optimal model. The nomogram was constructed with the optimal model. Results In the training cohort, independent predictors obtained from the combined model were DWI (OR 1822.741; 95 CI 6.189, 536,781.805; P = 0.01) and HBP enhancement pattern (OR 14.270; 95 CI 1.044, 195.039; P = 0.046). The combined model showed the good performance (AUC 0.981; 95 CI 0.952, 1.000) for predicting Ki-67 expression. In the validation cohort, The combined model (AUC 0.909; 95 CI 0.787, 1.000)showed the best performance compared to the clinical model (AUC 0.448; 95 CI 0.196, 0.700) and MRI model (AUC 0.770; 95 CI 0.570, 0.970). Conclusion This new nomogram has a good performance in predicting Ki-67 expression in patients with IMCC, which could help the decision-making of the patients' therapy strategies. GRAPHICS .

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来源
《Abdominal radiology.》 |2023年第2期|567-578|共12页
作者
Chen Xiang; Zhu Jingfen; Zou ZiguiDu MingzhanXie JunjianYe YujieZhang LingLi Yonggang;
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作者单位

Soochow University - China,Soochow Univ;

State Key Lab Oncology South China,State Key Lab Oncol South China;

Sun Yat Sen University,Sun Yat Sen Univ Canc Ctr;

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原文格式 PDF
正文语种英语
中图分类内科学;
关键词
Cholangiocarcinoma; Ki-67 expression; Magnetic resonance imaging; Prognosis; Liver neoplasms; HEPATOCELLULAR-CARCINOMA; ENHANCEMENT PATTERNS; RESECTION; CT;

Nomogram based on MRI for preoperative prediction of Ki-67 expression in patients with intrahepatic mass cholangiocarcinoma

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