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首页> 外文期刊>The journal of sexual medicine >Impaired Sexual Function in Young Women With PCOS: The Detrimental Effect of Anovulation
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Impaired Sexual Function in Young Women With PCOS: The Detrimental Effect of Anovulation

机译：Impaired Sexual Function in Young Women With PCOS: The Detrimental Effect of Anovulation

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Background: Even though polycystic ovary syndrome (PCOS) is a common reproductive disorder affecting young women, its impact on their sexual health is not well known. Aim: To examine the different aspects of female sexuality in young women with PCOS and attempt to associate hormonal changes and ovulatory status with their sexual function. Methods: Anthropometric characteristics, hormonal levels and sexual function based on the Female Sexual Function Index (FSFI) questionnaire were assessed in 76 young women with PCOS and 133 matched controls. Outcomes: Sexual function is significantly impaired in young women with PCOS. Results: Women with PCOS demonstrated lower scores than controls in arousal (5.04 +/- 1.19 vs 4.48 +/- 1.44, P < .001), lubrication (5.29 +/- 1.17 vs 4.69 +/- 1.54, P < .001), orgasm (4.78 +/- 1.40 vs 4.11 +/- 1.61, P = .001), satisfaction (5.22 +/- 1.10 vs 4.78 +/- 1.31, P = .016), and total score of the FSFI (29.51 +/- 5.83 vs 26.76 +/- 6.81, P < .001), even after correction for BMI. When corrected for total testosterone, the domains of lubrication, satisfaction, and total score of FSFI remained significantly impaired in women with PCOS (P values .037, .024, .044 respectively). In multivariate logistic regression analysis, after adjusting for the effect of BMI and hormone levels, dysfunction in orgasm, satisfaction and the total FSFI score were still 3-4 times more common in PCOS (adjusted OR 95 CI: 3.54, P = .020; 2.96, P = .050; 3.87, P = .027). Even though no statistically significant differences were observed between women with ovulatory PCOS and controls, we detected statistically significant differences in all domains of sexual function apart from pain between controls and PCOS women with anovulation (desire P value .04, arousal P value <.001, lubrication P value <.001, orgasm P value .001, satisfaction P value .001 and FSFI total score P value <.001). Clinical Implications: Women with PCOS have compromised sexual function, which is independent of their BMI and highly dependent on their ovulatory status. Strengths and Limitations: This is the first study in women with PCOS that implicates anovulation as a risk factor for sexual impairment in PCOS. Further studies are needed to elucidate the mechanisms implicated and to examine the effect of PCOS therapy on the patients' sexual function. Conclusion: The adverse effect of PCOS status on the female sexual function is independent of BMI and only partially dependent on hormonal changes characterizing the syndrome. Anovulation appears to be the major determinant of sexual impairment among women with PCOS. Copyright (C) 2021 The Authors. Published by Elsevier Inc. on behalf of the International Society for Sexual Medicine.

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