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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America. >Dual self-regulated delivery of insulin and glucagon by a hybrid patch
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Dual self-regulated delivery of insulin and glucagon by a hybrid patch

机译：Dual self-regulated delivery of insulin and glucagon by a hybrid patch

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Reduced beta-cell function and insulin deficiency are hallmarks of diabetes mellitus, which is often accompanied by the malfunction of glucagon-secreting alpha-cells. While insulin therapy has been developed to treat insulin deficiency, the on-demand supplementation of glucagon for acute hypoglycemia treatment remains inadequate. Here, we describe a transdermal patch that mimics the inherent counterregulatory effects of beta-cells and alpha-cells for blood glucose management by dynamically releasing insulin or glucagon. The two modules share a copolymerized matrix but comprise different ratios of the key monomers to be "dually responsive" to both hyperand hypoglycemic conditions. In a type 1 diabetic mouse model, the hybrid patch effectively controls hyperglycemia while minimizing the occurrence of hypoglycemia in the setting of insulin therapy with simulated delayed meal or insulin overdose.

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