RNA-based therapeutics to treat human fungal infections

Bruch A.; Kelani A.A.; Blango M.G.

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RNA-based therapeutics to treat human fungal infections

机译：RNA-based therapeutics to treat human fungal infections

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© 2021 Elsevier LtdIn recent decades, RNA-based therapeutics have transitioned from a near impossibility to a compelling treatment alternative for genetic disorders and infectious diseases. The mRNA vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are truly groundbreaking, and new adaptations are already being proposed to fight other microbes. Unfortunately, the potential of RNA-based therapeutics to treat human fungal infections has remained mostly absent from the conversation, despite the fact that invasive fungal infections kill as many per year as tuberculosis and even more than malaria. Here, we argue that RNA-based therapeutics should be investigated for the treatment of human fungal infections and discuss several major roadblocks and potential circumventions that may allow for the realization of RNA-based therapies against human fungal pathogens.

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《Trends in Microbiology》 |2022年第5期|411-420|共10页
作者
Bruch A.; Kelani A.A.; Blango M.G.;
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作者单位

Junior Research Group RNA Biology of Fungal Infections Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (Leibniz-HKI);

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原文格式 PDF
正文语种英语
中图分类微生物学;
关键词
antifungal; fungal infection; fungi; medical mycology; RNA-based therapeutics;

RNA-based therapeutics to treat human fungal infections

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