The cellular and molecular basis of somatosensory neuron development

Meltzer Shan; Santiago Celine; Sharma NikhilGinty David D.

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The cellular and molecular basis of somatosensory neuron development

机译：The cellular and molecular basis of somatosensory neuron development

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Primary somatosensory neurons convey salient information about our external environment and internal state to the CNS, allowing us to detect, perceive, and react to a wide range of innocuous and noxious stimuli. Pseudo-unipolar in shape, and among the largest (longest) cells of most mammals, dorsal root ganglia (DRG) somatosensory neurons have peripheral axons that extend into skin, muscle, viscera, or bone and central axons that innervate the spinal cord and brainstem, where they synaptically engage the central somatosensory circuitry. Here, we review the diversity of mammalian DRG neuron subtypes and the intrinsic and extrinsic mechanisms that control their development. We describe classical and contemporary advances that frame our understanding of DRG neurogenesis, transcriptional specification of DRG neurons, and the establishment of morphological, physiological, and synaptic diversification across somatosensory neuron subtypes.

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《Neuron》 |2021年第23期|3736-3757|共22页
作者
Meltzer Shan; Santiago Celine; Sharma NikhilGinty David D.;
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作者单位

Howard Hughes Med Inst,Harvard Med Sch;

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原文格式 PDF
正文语种英语
中图分类神经病学;
关键词
RAPIDLY ADAPTING MECHANORECEPTORS; PRIMARY AFFERENT-FIBERS; ROOT GANGLION NEURONS; NERVE GROWTH-FACTOR; SENSORY NEURONS; MUSCLE-SPINDLE; SPINAL-CORD; PRENATAL DEVELOPMENT; RECEPTOR GENE; ARTERIAL DIFFERENTIATION;

The cellular and molecular basis of somatosensory neuron development

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