A Critical Review on Transplacental Transfer of Per- and Polyfluoroalkyl Substances: Prenatal Exposure Levels, Characteristics, and Mechanisms

Ma Donghui; Lu Yao; Liang YongRuan TingLi JuanWang YaweiZhao ChunyanJiang Guibin

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A Critical Review on Transplacental Transfer of Per- and Polyfluoroalkyl Substances: Prenatal Exposure Levels, Characteristics, and Mechanisms

机译：A Critical Review on Transplacental Transfer of Per- and Polyfluoroalkyl Substances: Prenatal Exposure Levels, Characteristics, and Mechanisms

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摘要

Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances (PFASs)has aroused public concerns as it can pose multiple health threats to pregnant women andcause adverse birth outcomes for fetuses. In previous studies, the prenatal exposure levels andtransplacental transfer efficiencies (TTE) of PFASs have been reported and discussed.Specifically, the binding affinities between PFASs and some transporters were determined,demonstrating that the TTE values of PFASs are highly dependent on their binding behaviors.To summarize primaryfindings of previous studies and propose potential guidance for futureresearch, this article provides a systematic overview on levels and characteristics of prenatalexposure to PFASs worldwide, summarizes relationships between TTE values and structuresof PFASs, and discusses possible transplacental transfer mechanisms, especially for thecombination between PFASs and transporters. Given the critical roles of transporters in thetransplacental transfer of PFASs, we conducted molecular docking to further clarify thebinding behaviors between PFASs and the selected transporters. We proposed that themachine learning can be a superior method to predict and reveal behaviors and mechanisms of the transplacental transfer of PFASs.In total, this is thefirst review providing a comprehensive overview on the prenatal exposure levels and transplacental transfer mechanisms of PFASs.

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来源
《Environmental Science & Technology: ES&T》 |2022年第10期|6014-6026|共13页
作者
Ma Donghui; Lu Yao; Liang YongRuan TingLi JuanWang YaweiZhao ChunyanJiang Guibin;
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作者单位

Chinese Acad Sci;

Univ Chinese Acad Sci;

Jianghan UnivLanzhou Univ;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类环境科学、安全科学;
关键词
perfluoroalkyl and polyfluoroalkyl substances; prenatal exposure; transplacental transfer; molecular docking; quantitative structure-activity relationship; PERSISTENT ORGANIC POLLUTANTS; ETHER SULFONIC-ACIDS; PERFLUOROALKYL SUBSTANCES; PERFLUORINATED COMPOUNDS; PLACENTAL-TRANSFER; UMBILICAL-CORD; PERFLUOROOCTANOIC ACID; FETAL EXPOSURE; MASS-SPECTROMETRY; PREGNANT-WOMEN;

A Critical Review on Transplacental Transfer of Per- and Polyfluoroalkyl Substances: Prenatal Exposure Levels, Characteristics, and Mechanisms

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