Low‐Trauma Fracture Increases 12‐Month Incidence of Cardiovascular Disease for Adults With Cerebral Palsy

Daniel G. Whitney; Rachael T. Whitney; Rhonda D. PrisbyKarl J. Jepsen

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Low‐Trauma Fracture Increases 12‐Month Incidence of Cardiovascular Disease for Adults With Cerebral Palsy

机译：Low‐Trauma Fracture Increases 12‐Month Incidence of Cardiovascular Disease for Adults With Cerebral Palsy

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ABSTRACT Individuals with cerebral palsy (CP) have poor skeletal and cardiovascular health. However, no studies have examined if skeletal fragility enhances cardiovascular disease (CVD) risk for this population. The purpose of this study was to determine whether adults with CP have higher 12‐month CVD incidence following a low‐trauma fracture compared with adults without CP. Data, from the Optum Clinformatics? Data Mart, were extracted from adults (18+ years) that sustained a low‐trauma fracture between 01/01/2012 and 12/31/2016. The primary outcome measure was incident CVD within 12 months following a low‐trauma fracture. Cox proportional hazards regression models were used to compare 12‐month incident CVD with adjustment for sociodemographics and chronic disease comorbidities. Mean age (SD) at baseline was 54.7 (18.9) for adults with CP (n?=?1,025, 43.3 men) and 60.4 (19.7) for adults without CP (n?=?460,504, 33.7 men). During the follow‐up, 121 adults with CP (11.8, mean age SD?=?63.9 16.3) and 45,330 adults without CP (9.8, mean age SD?=?74.5 11.9) developed CVD. In the fully adjusted model, adults with CP had higher 12‐month post‐fracture CVD incidence (hazard ratio HR?=?1.63; 95 confidence interval CI?=?1.37–1.95). When the outcome was stratified by CVD subtype, adults with CP had higher 12‐month post‐fracture incidence of ischemic heart disease (HR?=?1.45; 95 CI?=?1.09–1.92), heart failure (HR?=?1.68; 95 CI?=?1.22–2.31), and cerebrovascular disease (HR?=?1.96; 95 CI?=?1.54–2.50). Study findings suggest that among adults with CP, low‐trauma fracture may enhance 12‐month CVD incidence compared with adults without CP. ? 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:803‐810, 2020

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《Journal of orthopaedic research》 |2020年第4期|803-810|共8页
作者
Daniel G. Whitney; Rachael T. Whitney; Rhonda D. PrisbyKarl J. Jepsen;
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作者单位

Department of Physical Medicine and Rehabilitation,University of Michigan;

Department of Kinesiology and Applied Physiology,University of Delaware;

Department of Kinesiology,University of Texas at ArlingtonDepartment of Orthopaedic Surgery,University of Michigan;

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正文语种英语
中图分类骨科学（运动系疾病、矫形外科学）;
关键词
fracture; cerebral palsy; cardiovascular disease; clinical epidemiology; osteoporosis;

Low‐Trauma Fracture Increases 12‐Month Incidence of Cardiovascular Disease for Adults With Cerebral Palsy

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