Circadian dynamics of the teleost skin immune-microbiome interface

Amy R. Ellison; Ellison Amy R; David WilcocksonWilcockson DavidJo CableCable Jo

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Circadian dynamics of the teleost skin immune-microbiome interface

机译：Circadian dynamics of the teleost skin immune-microbiome interface

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Background Circadian rhythms of host immune activity and their microbiomes are likely pivotal to health and disease resistance. The integration of chronotherapeutic approaches to disease mitigation in managed animals, however, is yet to be realised. In aquaculture, light manipulation is commonly used to enhance growth and control reproduction but may have unknown negative consequences for animal health. Infectious diseases are a major barrier to sustainable aquaculture and understanding the circadian dynamics of fish immunity and crosstalk with the microbiome is urgently needed. Results Here, using rainbow trout ( Oncorhynchus mykiss ) as a model, we combine 16S rRNA metabarcoding, metagenomic sequencing and direct mRNA quantification methods to simultaneously characterise the circadian dynamics of skin clock and immune gene expression, and daily changes of skin microbiota. We demonstrate daily rhythms in fish skin immune expression and microbiomes, which are modulated by photoperiod and parasitic lice infection. We identify putative associations of host clock and immune gene profiles with microbial composition. Our results suggest circadian perturbation, that shifts the magnitude and timing of immune and microbiota activity, is detrimental to fish health. Conclusions The substantial circadian dynamics and fish host expression-microbiome relationships we find represent a valuable foundation for investigating the utility of chronotherapies in aquaculture, and more broadly contributes to our understanding of the role of microbiomes in circadian health of vertebrates.

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《microbiome》 |2021年第1期|222-239|共18页
作者
Amy R. Ellison; Ellison Amy R; David WilcocksonWilcockson DavidJo CableCable Jo;
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作者单位

School of Natural Sciences, Bangor University;

Institute of Biological, Environmental and Rural Sciences (IBERS), Aberystwyth University;

School of Biosciences, Cardiff University;

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正文语种英语
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Aquaculture; Circadian rhythm; Clock gene expression; Fish; Immunity; Metagenome; Microbiome; Parasite infection; Photoperiod;

Circadian dynamics of the teleost skin immune-microbiome interface

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