New Approach Methodologies for the Endocrine Activity Toolbox: Environmental Assessment for Fish and Amphibians

Constance A. Mitchell; Natalie Burden; Mark BonnellMarkus HeckerThomas H. HutchinsonMagdalena JaglaCarlie A. LaLoneLaurent LagadicScott G. LynnBryon ShoreYou SongSara M. VlietJames R. WheelerMichelle R. Embry

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New Approach Methodologies for the Endocrine Activity Toolbox: Environmental Assessment for Fish and Amphibians

机译：New Approach Methodologies for the Endocrine Activity Toolbox: Environmental Assessment for Fish and Amphibians

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Multiple in vivo test guidelines focusing on the estrogen, androgen, thyroid, and steroidogenesis pathways havebeen developed and validated for mammals, amphibians, or fish. However, these tests are resource‐intensive and often use alarge number of laboratory animals. Developing alternatives for in vivo tests is consistent with the replacement, reduction,and refinement principles for animal welfare considerations, which are supported by increasing mandates to move toward an“animal‐free” testing paradigm worldwide. New approach methodologies (NAMs) hold great promise to identify molecular,cellular, and tissue changes that can be used to predict effects reliably and more efficiently at the individual level (andpotentially on populations) while reducing the number of animals used in (eco)toxicological testing for endocrine disruption.In a collaborative effort, experts from government, academia, and industry met in 2020 to discuss the current challenges oftesting for endocrine activity assessment for fish and amphibians. Continuing this cross‐sector initiative, our review focuseson the current state of the science regarding the use of NAMs to identify chemical‐induced endocrine effects. The presentstudy highlights the challenges of using NAMs for safety assessment and what work is needed to reduce their uncertaintiesand increase their acceptance in regulatory processes. We have reviewed the current NAMs available for endocrine activityassessment including in silico, in vitro, and eleutheroembryo models. New approach methodologies can be integrated aspart of a weight‐of‐evidence approach for hazard or risk assessment using the adverse outcome pathway framework. Thedevelopment and utilization of NAMs not only allows for replacement, reduction, and refinement of animal testing but canalso provide robust and fit‐for‐purpose methods to identify chemicals acting via endocrine mechanisms.

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《Environmental toxicology and chemistry /》 |2023年第4期|757-777|共21页
作者
Constance A. Mitchell; Natalie Burden; Mark BonnellMarkus HeckerThomas H. HutchinsonMagdalena JaglaCarlie A. LaLoneLaurent LagadicScott G. LynnBryon ShoreYou SongSara M. VlietJames R. WheelerMichelle R. Embry;
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作者单位

Environment and Climate Change Canada, Ottawa, Canada;

Office of Research and Development, Great Lakes Toxicology & Ecology Division, US Environmental Protection Agency, Duluth, Minnesota;

Research and Development, Crop Science, Environmental Safety, Bayer, Monheim am Rhein, GermanyOffice of Pesticide Programs, US Environmental Protection Agency, Washington, DCNorwegian Institute for Water Research, Oslo, NorwayOffice of Research and Development, Scientific Computing and Data Curation Division, US Environmental Protection Agency, Duluth, MinnesotaCorteva Agriscience, Bergen op Zoom, The NetherlandsThe Health and Environmental Sciences Institute, Washington, DC, USANational Centre for the 3Rs (NC3Rs), London, United KingdomToxicology Centre and School of the Environment & Sustainability, University of Saskatchewan, Saskatoon, CanadaReckitt R&D, Hull, United Kingdom;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
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关键词
Adverse outcome pathway; Endocrine‐disrupting compounds; In vitro toxicology;

New Approach Methodologies for the Endocrine Activity Toolbox: Environmental Assessment for Fish and Amphibians

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