Bifidobacterium animalis subsp. lactis Probio-M8 undergoes host adaptive evolution by glcU mutation and translocates to the infant's gut via oral-/entero-mammary routes through lactation

Zhong Zhi; Tang Hai; Shen TingtingMa XinweiZhao FeiyanKwok Lai-YuSun ZhihongBilige MengheZhang Heping

首页> 外文期刊>microbiome >Bifidobacterium animalis subsp. lactis Probio-M8 undergoes host adaptive evolution by glcU mutation and translocates to the infant's gut via oral-/entero-mammary routes through lactation

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Bifidobacterium animalis subsp. lactis Probio-M8 undergoes host adaptive evolution by glcU mutation and translocates to the infant's gut via oral-/entero-mammary routes through lactation

机译：Bifidobacterium animalis subsp. lactis Probio-M8 undergoes host adaptive evolution by glcU mutation and translocates to the infant's gut via oral-/entero-mammary routes through lactation

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Background: Most previous studies attempting to prove the phenomenon of mother-to-infant microbiota transmission were observational, performed only at genus/species-level resolution, and relied entirely on non-culture-based methodologies, impeding interpretation. Results: This work aimed to use a biomarker strain, Bifidobacterium animalis subsp. lactis Probio-M8 (M8), to directly evaluate the vertical transmission of maternally ingested bacteria by integrated culture-dependent/-independent methods. Our culture and metagenomics results showed that small amounts of maternally ingested bacteria could translocate to the infant gut via oral-/entero-mammary routes through lactation. Interestingly, many mother-infant-pair-recovered M8 homologous isolates exhibited high-frequency nonsynonymous mutations in a sugar transporter gene (glcU) and altered carbohydrate utilization preference/capacity compared with non-mutant isolates, suggesting that M8 underwent adaptive evolution for better survival in simple sugar-deprived lower gut environments. Conclusions: This study presented direct and strain-level evidence of mother-to-infant bacterial transmission through lactation and provided insights into the impact of milk microbiota on infant gut colonization.

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《microbiome》 |2022年第1期|共14页
作者
Zhong Zhi; Tang Hai; Shen TingtingMa XinweiZhao FeiyanKwok Lai-YuSun ZhihongBilige MengheZhang Heping;
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作者单位

Inner Mongolia Agr Univ;

Inner Mongolia Agr Univ;

Inner Mongolia Key Lab Dairy Biotechnol & Engn;

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正文语种英语
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Bifidobacteria; Gut microbiota; Mother-to-infant bacterial transmission; Lactation; Adaptive evolution; glcU; IMMUNE-SYSTEM; MICROBIOTA; TRANSMISSION; BACTERIA; SEQUENCE; REVEALS; GENOMES; SHAPES; GENES; MILK;

Bifidobacterium animalis subsp. lactis Probio-M8 undergoes host adaptive evolution by glcU mutation and translocates to the infant's gut via oral-/entero-mammary routes through lactation

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