Dynamics of a disinhibitory prefrontal microcircuit in controlling social competition

Zhang Chaoyi; Zhu Hong; Ni ZheyiXin QiuhongZhou TingtingWu RunlongGao GuangpingGao ZhihuaMa HuanLi HaohongHe MiaoZhang JueCheng HepingHu Hailan

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Dynamics of a disinhibitory prefrontal microcircuit in controlling social competition

机译：Dynamics of a disinhibitory prefrontal microcircuit in controlling social competition

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Social competition plays a pivotal role in determining individuals' social status. While the dorsomedial prefrontal cortex (dmPFC) is essential in regulating social competition, it remains unclear how information is processed within its local networks. Here, by applying optogenetic and chemogenetic manipulations in a dominance tube test, we reveal that, in accordance with pyramidal (PYR) neuron activation, excitation of the vasoactive intestinal polypeptide (VIP) or inhibition of the parvalbumin (PV) interneurons induces winning. The winning behavior is associated with sequential calcium activities initiated by VIP and followed by PYR and PV neurons. Using miniature two-photon microscopic (MTPM) and optrode recordings in awake mice, we show that VIP stimulation directly leads to a two-phased activity pattern of both PYR and PV neurons-rapid suppression followed by activation. The delayed activation of PV implies an embedded feedback tuning. This disinhibitory VIP-PV-PYR motif forms the core of a dmPFC microcircuit to control social competition.

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来源
《Neuron》 |2022年第3期|516-531|共16页
作者
Zhang Chaoyi; Zhu Hong; Ni ZheyiXin QiuhongZhou TingtingWu RunlongGao GuangpingGao ZhihuaMa HuanLi HaohongHe MiaoZhang JueCheng HepingHu Hailan;
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作者单位

Dept Psychiat,Zhejiang Univ;

PKU Nanjing Inst Translat Med,Chinese Acad Med Sci;

Horae Gene Therapy Ctr,Univ MassachusettsMOE Frontier Res Ctr Brain & Brain Machine Integr,Zhejiang UnivState Key Lab Med Neurobiol,Fudan Univ;

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原文格式 PDF
正文语种英语
中图分类神经病学;
关键词
MINIATURE 2-PHOTON MICROSCOPY; MEDIAL FRONTAL-CORTEX; SOMATOSTATIN INTERNEURONS; NEURAL MECHANISMS; DECISION-MAKING; VISUAL-CORTEX; INHIBITION; NEURONS; EXCITATION; CIRCUITS;

Dynamics of a disinhibitory prefrontal microcircuit in controlling social competition

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