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Physical Cue-Based Strategies on Peripheral Nerve Regeneration

机译：Physical Cue-Based Strategies on Peripheral Nerve Regeneration

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摘要

Peripheral nerve injury (PNI) remains an intractable challenge in regenerativemedicine. Recently, physical cue-based strategies (e.g., electrical neurostimulation,acoustic radiation, electromagnetic bioregulation, as well asdirectional fiber guiding, etc.) have drawn increasing attention not only as astimulator for cell functions modulation and fate determination, but also as amorphology-index for modulating cell phenotype, proliferation, and differentiation,especially for nerve cells. More importantly, the advanced percutaneouspower transmission technology, self-power nanotechnology that leveragespiezoelectrical/triboelectricity materials, and focused ultrasound and pulsedelectromagnetic field technology exhibit the appealing practice potential forachieving low-invasive, wireless, and battery-free neuromodulation. In thisreview, recent advances of physical cue-based strategies including electrical,acoustic, magnetic, and morphology for PNI are systematically overviewed,and the open challenges for realizing scalable clinical/commercial transformationand future perspectives of these strategies for PNI are concluded.

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