Smart Biomaterials for Articular Cartilage Repair and Regeneration

Zhanghao Gu; Jiayi Wang; Yu FuHao PanHongyan HeQi GanChangsheng Liu

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Smart Biomaterials for Articular Cartilage Repair and Regeneration

机译：Smart Biomaterials for Articular Cartilage Repair and Regeneration

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摘要

Articular cartilage defects bring about disability and worldwide socioeconomicloss, therefore, articular cartilage repair and regeneration is recognizedas a global issue. However, due to its avascular and nearly acellular characteristic,cartilage tissue regeneration ability is limited to some extent. Despitethe availability of various treatment methods, including palliative drugs andsurgical regenerative therapy, articular cartilage repair and regeneration stillface major challenges due to the lack of appropriate methods and materials.Smart biomaterials can regulate cell behavior and provide excellent tissuerepair and regeneration microenvironment, thus inducing articular cartilagerepair and regeneration. This process is adjusted by controlling drug/bioactive factors release via responding to exogenous/endogenous stimuli,tailoring materials’ structure and function similar to native cartilage orproviding physiochemical and physical signaling factors. Herein, smart biomaterials,recently applied in articular cartilage repair and regeneration, areelaborated from two aspects: smart drug release system and smart scaffolds.Furthermore, articular cartilage and its defects and advanced manufacturingtechniques of smart biomaterials are discussed in brief. Finally, perspectivesfor smart biomaterials used in articular cartilage repair and regeneration arepresented and the clinical translation of smart biomaterials is emphasized.

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来源
《Advanced functional materials》 |2023年第10期|2212561.1-2212561.24|共24页
作者
Zhanghao Gu; Jiayi Wang; Yu FuHao PanHongyan HeQi GanChangsheng Liu;
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作者单位

Key Laboratory for Ultrafine Materials of Ministry of EducationEast China University of Science and TechnologyShanghai 200237, P. R. China, School of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237, P. R. Ch;

School of Aerospace Engineering and Applied MechanicsTongji UniversityZhangwu Road 100, Shanghai 200092, P. R. China;

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正文语种英语
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关键词
articular cartilage repair; articular cartilage regeneration; smart biomaterials; smart drug release; smart scaffolds;

Smart Biomaterials for Articular Cartilage Repair and Regeneration

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