Comparison of Serologic Response of Hospitalized COVID-19 Patients Using 8 Immunoassays

Sun Min Lee; In-Suk Kim; Seungjin LimSu Jin LeeWon-Joo KimKyung-Hwa ShinSoo Young MoonChulhun L. Chang

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Comparison of Serologic Response of Hospitalized COVID-19 Patients Using 8 Immunoassays

机译：Comparison of Serologic Response of Hospitalized COVID-19 Patients Using 8 Immunoassays

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BACKGROUND:In Korea, there were issues regarding the use of immunoassays for anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies to detect infection. So, we compared antibody results of eight kinds of commercial immunoassays using clinical remnant specimens.METHODS:We compared the results of several immunoassay kits tested on 40 serum samples from 15 confirmed patients and 86 remnant serum samples from clinical laboratory. Eight kinds of IVD kits-four enzyme-linked immunosorbent assay, two lateral flow rapid immunochromatographic assays, and two chemiluminescent immunoassays with one RUO kit were tested.RESULTS:Among 40 serum samples from 15 coronavirus disease 2019 (COVID-19) patients, 35 yielded at least one positive result for detecting antibodies in the combined assessment. There were inconsistent results in 12 (28) samples by single immunoassay. Forty samples collected in 2019 before the first COVID-19 Korean case showed negative results except for one equivocal result.CONCLUSION:The discrepant results obtained with different immunoassay kits in this study show that serological assessment of SARS-CoV-2 by a single immunoassay requires caution not only in detecting infection but also in assessing immunologic status.© 2021 The Korean Academy of Medical Sciences.

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《Journal of Korean medical science.》 |2021年第9期|1-8|共8页
作者
Sun Min Lee; In-Suk Kim; Seungjin LimSu Jin LeeWon-Joo KimKyung-Hwa ShinSoo Young MoonChulhun L. Chang;
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Department of Laboratory Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine;

Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital;

Department of Laboratory Medicine, Pusan National University School of MedicineDivision of Infection, Department of Internal Medicine, Pusan National University Yangsan HospitalDepartment of Laboratory Medicine, Pusan National University HospitalDepartment of Laboratory Medicine, Seoul Medical Center;

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正文语种英语
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Antibodies; COVID-19; ELISA; Immunoassay; Korea; SARS-CoV-2;

Comparison of Serologic Response of Hospitalized COVID-19 Patients Using 8 Immunoassays

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