Polyphenolic Natural Products Active In Silico Against SARS-CoV-2 Spike Receptor Binding Domains and Non-structural Proteins - A Review

Mark Quimque; Kin Notarte; Xela AdvientoMikhail CabunocVon de LeonFelippe delos ReyesEiron LugtuJoe ManzanoSofia MontonJohn Mu?ozKatherine OngDelfin PilapilVito RoqueSophia TanJustin LimAllan Macabeo

首页> 外文期刊>Combinatorial chemistry & high throughput screening >Polyphenolic Natural Products Active In Silico Against SARS-CoV-2 Spike Receptor Binding Domains and Non-structural Proteins - A Review

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Polyphenolic Natural Products Active In Silico Against SARS-CoV-2 Spike Receptor Binding Domains and Non-structural Proteins - A Review

机译：Polyphenolic Natural Products Active In Silico Against SARS-CoV-2 Spike Receptor Binding Domains and Non-structural Proteins - A Review

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The ongoing Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic has been proven to be more severe than the previous coronavirus outbreaks due to the virus’ high transmissibility. With the emergence of new variants, this global phenomenon took a more dramatic turn, with many countries recently experiencing higher surges of confirmed cases and deaths. On top of this, the inadequacy of effective treatment options for COVID-19 aggravated the problem. As a way to address the unavailability of target-specific viral therapeutics, computational strategies have been employed to hasten and systematize the search. The objective of this review is to provide initial data highlighting the utility of polyphenols as potential prophylaxis or treatment for COVID-19. In particular, presented here are virtually screened polyphenolic compounds which showed potential as either antagonists to viral entry and host cell recognition through binding with various receptor-binding regions of SARS-CoV-2 spike protein or as inhibitors of viral replication and post-translational modifications through binding with essential SARS-CoV-2 non-structural proteins.

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《Combinatorial chemistry & high throughput screening》 |2023年第3期|459-488|共30页
作者
Mark Quimque; Kin Notarte; Xela AdvientoMikhail CabunocVon de LeonFelippe delos ReyesEiron LugtuJoe ManzanoSofia MontonJohn Mu?ozKatherine OngDelfin PilapilVito RoqueSophia TanJustin LimAllan Macabeo;
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作者单位

University of Santo Tomas,Laboratory for Organic Reactivity, Discovery and Synthesis (LORDS),;

University of Santo Tomas,Faculty of Medicine and Surgery,Espana Blvd., Manila 1015,Manila;

University of Santo Tomas,Department of Medical Technology, Faculty of Pharmacy,Espana Blvd.,University of Santo Tomas,Department of Medical Technology, Faculty of Pharmacy,Manila,Philippines,University of Santo Tomas,Department of Biological Sciences, College of Science,Espana Blvd.,University of the Philippines Baguio,Department of Biology,Governor Pack Road, Baguio City 2600University of Santo Tomas,University of Santo Tomas,Espana Blvd., Manila 1015,Manila,Philippines,Department of Medical Technology, Faculty of Pharmacy, University of Santo Tomas, Espana Blvd.,Laboratory for Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for the Natural;

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正文语种英语
中图分类化学;
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Polyphenols; COVID-19; SARS-CoV-2; molecular docking; flavonoids; Non-structural proteins.;

Polyphenolic Natural Products Active In Silico Against SARS-CoV-2 Spike Receptor Binding Domains and Non-structural Proteins - A Review

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