Gut microbiota response to antibiotics is personalized and depends on baseline microbiota

Armin Rashidi; Maryam Ebadi; Tauseef Ur RehmanHeba ElhusseiniHarika NalluriThomas KaiserShernan G. HoltanAlexander KhorutsDaniel J. WeisdorfChristopher Staley

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Gut microbiota response to antibiotics is personalized and depends on baseline microbiota

机译：Gut microbiota response to antibiotics is personalized and depends on baseline microbiota

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BACKGROUND:The magnitude of microbiota perturbations after exposure to antibiotics varies among individuals. It has been suggested that the composition of pre-treatment microbiota underpins personalized responses to antibiotics. However, this hypothesis has not been directly tested in humans. In this high-throughput amplicon study, we analyzed 16S ribosomal RNA gene sequences of 260 stool samples collected twice weekly from 39 patients with acute leukemia during their ~ 4 weeks of hospitalization for chemotherapy while they received multiple antibiotics.RESULTS:Despite heavy and sustained antibiotic pressure, microbial communities in samples from the same patient remained more similar to one another than to those from other patients. Principal component mixed effect regression using microbiota and granular antibiotic exposure data showed that microbiota departures from baseline depend on the composition of the pre-treatment microbiota. Penalized generalized estimating equations identified 6 taxa within pre-treatment microbiota that predicted the extent of antibiotic-induced perturbations.CONCLUSIONS:Our results indicate that specific species in pre-treatment microbiota determine personalized microbiota responses to antibiotics in humans. Thus, precision interventions targeting pre-treatment microbiota may prevent antibiotic-induced dysbiosis and its adverse clinical consequences. Video abstract.

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《microbiome》 |2021年第1期|211-221|共11页
作者
Armin Rashidi; Maryam Ebadi; Tauseef Ur RehmanHeba ElhusseiniHarika NalluriThomas KaiserShernan G. HoltanAlexander KhorutsDaniel J. WeisdorfChristopher Staley;
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作者单位

Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, 14-100 PWB, MMC 480;

Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Minnesota;

Department of Surgery, University of Minnesota;

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正文语种英语
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Antibiotics; Leukemia; Microbiota;

Gut microbiota response to antibiotics is personalized and depends on baseline microbiota

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