Mechanobiological model to study the influence of screw design and surface treatment on osseointegration

Rousseau Nicolas; Chabrand Patrick; Destainville ArnaudRichart OlivierMilan Jean-Louis

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Mechanobiological model to study the influence of screw design and surface treatment on osseointegration

机译：Mechanobiological model to study the influence of screw design and surface treatment on osseointegration

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This study aims at suggesting a new approach to peri-implant healing models, providing a set of taxis-diffusion-reaction equations under the combined influence of mechanical and biochemical factors. Early events of osseointegration were simulated for titanium screw implants inserted into a pre-drilled trabecular bone environment, up to 12 weeks of peri-implant bone healing. Simulations showed the ability of the model to reproduce biological events occurring at the implant interface through osteogenesis. Implants with shallow healing chamber showed higher proportions of lamellar bone, enhanced by the increase of mechanical stimulation. Osteoconduction was observed through the surface treatment model and similar bone healing patterns compared to in vivo studies.

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《Computer methods in biomechanics and biomedical engineering》 |2022年第4期|273-289|共17页
作者
Rousseau Nicolas; Chabrand Patrick; Destainville ArnaudRichart OlivierMilan Jean-Louis;
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作者单位

Aix Marseille Univ, ISM, CNRS, Marseille, France|Selenium Med, 9049 Rue Quebec,CS80875, F-17043 La Rochelle, France;

Aix Marseille Univ, ISM, CNRS, Marseille, France;

Abys Med, La Rochelle, FranceSelenium Med, 9049 Rue Quebec,CS80875, F-17043 La Rochelle, France;

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正文语种英语
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Osseointegration; mechanobiological model; implant design; surface treatment; finite element simulation;

Mechanobiological model to study the influence of screw design and surface treatment on osseointegration

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