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首页> 外文期刊>Acta oncologica. >When breast cancer comes to the ICU: outcomes and prognostic factors
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When breast cancer comes to the ICU: outcomes and prognostic factors

机译：When breast cancer comes to the ICU: outcomes and prognostic factors

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BackgroundBreast cancer is the most prevalent neoplasm in women in North American and European countries. Data about intensive care unit (ICU) requirements and the related outcomes are scarce. Furthermore, long-term outcome after ICU discharge has not been described.Material and methodsWe conducted a retrospective monocenter study including patients with breast cancer requiring unplanned ICU admission over a 14-year period (2007-2020).Results177 patients (age = 6557-75 years) were analyzed. Breast cancer was at a metastatic stage for 122 (68.9) patients, recently diagnosed in 25 (14.1) patients or in progression under treatment in 76 (42.9) patients. Admissions were related to sepsis in 56 (31.6) patients, to iatrogenic/procedural complication in 19 (10.7) patients and to specific oncological complications in 47 (26.6) patients. Seventy-two (40.7) patients required invasive mechanical ventilation, 57 (32.2) vasopressors/inotropes, and 26 (14.7) renal replacement therapy. In-ICU and one-year mortality rates were 20.9 and 57.1, respectively. Independent factors associated with in-ICU mortality were invasive mechanical ventilation and impaired performance status. One-year mortality in ICU survivors was independently associated with specific complications, triple negative cancer, and impaired performance status. After hospital discharge, most patients (77.4) were able to continue or initiate antitumoral treatment.ConclusionICU admission was linked to the underlying malignancy in one-quarter of breast cancer patients. Despite the low in-ICU mortality rate (20.9) and thereafter continuation of cancer treatment in most survivors (77.4), one-year mortality reached 57.1. Impaired performance status prior to the acute complication was a potent predictor of both short-term and long-term outcomes.

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