A Universal Chemotactic Targeted Delivery Strategy for Inflammatory Diseases

Ting Li; Zhiyong Liu; Jinglei HuLin ChenTiantian ChenQianqian TangBixia YuBo ZhaoChun MaoMimi Wan

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A Universal Chemotactic Targeted Delivery Strategy for Inflammatory Diseases

机译：A Universal Chemotactic Targeted Delivery Strategy for Inflammatory Diseases

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Above 50 of deaths can be attributed to chronic inflammatory diseases;thus, the construction of drug delivery systems based on effective interactionof inflammatory factors with chemotactic nanoparticles is meaningful.Herein, a zwitterion-based artificial chemotactic nanomotor is proposed foruniversal precise targeting strategy in vivo, where the high level of reactiveoxygen species (ROS) and inducible nitric oxide synthase (iNOS) in inflammatorysites are used as a chemoattractant. Multidimensional static models,dynamic models, and in vivo models are established to evaluate chemotacticperformance. The results show that the upregulated ROS and iNOS caninduce the chemotaxis of nanomotors to diseased tissues in inflammationrelateddisease models. Further, mesoscale hydrodynamics simulations areperformed to explain the chemotactic behavior of the nanomotors. Such achemotactic delivery strategy is expected to improve delivery efficiency andmay be applicable to a variety of inflammatory diseases.

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来源
《Advanced Materials》 |2022年第47期|2206654.1-2206654.15|共15页
作者
Ting Li; Zhiyong Liu; Jinglei HuLin ChenTiantian ChenQianqian TangBixia YuBo ZhaoChun MaoMimi Wan;
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作者单位

National and Local Joint Engineering Research Center of BiomedicalFunctional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023, China;

Kuang Yaming Honors SchoolNanjing UniversityNanjing 210023, China;

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正文语种英语
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chemotaxis; inducible nitric-oxide synthase; nanomotors; reactive oxide species; targeted delivery;

A Universal Chemotactic Targeted Delivery Strategy for Inflammatory Diseases

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