Metabolomics Signature for Non‐Responders to Total Joint Replacement Surgery in Primary Osteoarthritis Patients: The Newfoundland Osteoarthritis Study

Christie A. Costello; Ting Hu; Ming LiuWeidong ZhangAndrew FureyZhaozhi FanProton RahmanEdward W. RandellGuangju Zhai

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Metabolomics Signature for Non‐Responders to Total Joint Replacement Surgery in Primary Osteoarthritis Patients: The Newfoundland Osteoarthritis Study

机译：Metabolomics Signature for Non‐Responders to Total Joint Replacement Surgery in Primary Osteoarthritis Patients: The Newfoundland Osteoarthritis Study

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ABSTRACT Although total joint replacement (TJR) surgery is considered as the most effective treatment for advanced osteoarthritis (OA) patients, up to one‐third of patients reported unfavorable long‐term post‐operative pain outcomes. We aimed to identify metabolic biomarkers to predict non‐responders to TJR using a metabolomics approach. TJR patients were recruited and followed‐up at least 1‐year post‐surgery; TJR outcomes were assessed by Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain and function subscales. Targeted metabolomic profiling was performed on plasma samples collected pre‐surgery and pairwise metabolite ratios, as proxies for enzymatic reactions, were calculated. Association tests were performed between each metabolite ratio and non‐responders. The metabolome‐wide significance was defined as p?

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《Journal of orthopaedic research》 |2020年第4期|793-802|共10页
作者
Christie A. Costello; Ting Hu; Ming LiuWeidong ZhangAndrew FureyZhaozhi FanProton RahmanEdward W. RandellGuangju Zhai;
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作者单位

Discipline of Genetics, Faculty of Medicine,Memorial University of Newfoundland;

Department of Computer Science, Faculty of Science,Memorial University of Newfoundland;

Division of Orthopaedic Surgery, Faculty of Medicine,Memorial University of NewfoundlandDepartment of Mathematics and Statistics, Faculty of Science,Memorial University of NewfoundlandDiscipline of Medicine, Faculty of Medicine,Memorial University of NewfoundlandDiscipline of Laboratory Medicine, Faculty of Medicine,Memorial University of Newfoundland;

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正文语种英语
中图分类骨科学（运动系疾病、矫形外科学）;
关键词
osteoarthritis; total joint replacement; biomarkers; metabolomics;

Metabolomics Signature for Non‐Responders to Total Joint Replacement Surgery in Primary Osteoarthritis Patients: The Newfoundland Osteoarthritis Study

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