Whole-Genome Sequencing Reveals Germ Cell Mutagenicity of α-Endosulfan in Caenorhabditis elegans

Zhenxiao Cao; Meimei Wang; Tong Zhou

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Whole-Genome Sequencing Reveals Germ Cell Mutagenicity of α-Endosulfan in Caenorhabditis elegans

机译：Whole-Genome Sequencing Reveals Germ Cell Mutagenicity of α-Endosulfan in Caenorhabditis elegans

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Endosulfan is an extensively used organochlorine pesticide around the world, which was classified as a persistent organic pollutant (POP) in 2009. Although previous studies have documented the reproductive toxicity of endosulfan in a variety of organisms, little is known about the influence of endosulfan on the genome stability of germ cells and nonexposed progeny. Here we applied whole-genome sequencing to explore the germ cell mutagenicity of α-endosulfan in Caenorhabditis elegans (C. elegans). We found that, although low doses of α-endosulfan exhibited a minor effect on the reproductive capacity of C. elegans, chronic exposure to 1 μM α-endosulfan significantly increased the mutation firequencies of nonexposed progeny. Further analysis of genome-wide mutation spectra demonstrated that a- endosulfan preferentially elicited A:T → G.C substitutions and clustered mutations. By using worms deficient in DNA damage response genes, our results suggest the involvement of translesion synthesis polymerase η in modulating α-endosulfan-induced mutations in germ cells. Together, these observations reveal the germ cell mutagenicity of a-endosulfan in C. elegans and the possible underlying mechanism. In addition, our findings implicate that germ cell mutagenicity might be a necessary consideration for the health risk assessment of environmental chemicals such as POPs.

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《Environmental Science & Technology: ES&T》 |2022年第22期|16024-16032|共9页
作者
Zhenxiao Cao; Meimei Wang; Tong Zhou;
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作者单位

School of Environmental Science and Optoelectronic Technology, University of Science and Technology of China, Hefei 230026 Anhui, P. R. China;

Department of Pathophysiology, School of Basic Medical Science, Anhui Medical University, Hefei 230032 Anhui, P. R. China;

Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, CAS;

Anhui Province Key Laboratory of Environmental Toxicology and Pollution Control Technology, Hefei Institutes of Physical Science, CAS, Hefei 230031 Anhui, P. R. China;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类环境科学、安全科学;
关键词
α-endosulfan; Caenorhabditis elegans; germ cell mutagenicity; next-generation sequencing;

Whole-Genome Sequencing Reveals Germ Cell Mutagenicity of α-Endosulfan in Caenorhabditis elegans

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