AtINO80 represses photomorphogenesis by modulating nucleosome density and H2A.Z incorporation in light-related genes

Yang Chuanwei; Yin Liufan; Xie FaminMa MengmengHuang ShaZeng YueShen Wen-HuiDong AiwuLi Lin

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America. >AtINO80 represses photomorphogenesis by modulating nucleosome density and H2A.Z incorporation in light-related genes

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AtINO80 represses photomorphogenesis by modulating nucleosome density and H2A.Z incorporation in light-related genes

机译：AtINO80 represses photomorphogenesis by modulating nucleosome density and H2A.Z incorporation in light-related genes

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Photomorphogenesis is a critical developmental process bridging light-regulated transcriptional reprogramming with morphological changes in organisms. Strikingly, the chromatin-based transcriptional control of photomorphogenesis remains poorly understood. Here, we show that the Arabidopsis (Arabidopsis thaliana) ortholog of ATP-dependent chromatin-remodeling factor AtINO80 represses plant photomorphogenesis. Loss of AtINO80 inhibited hypocotyl cell elongation and caused anthocyanin accumulation. Both light-induced genes and dark-induced genes were affected in the atino80 mutant. Genome-wide occupancy of the H2A.Z histone variant and levels of histone H3 were reduced in atino80. In particular, AtINO80 bound the gene body of ELONGATED HYPOCOTYL 5 (HY5), resulting in lower chromatin incorporations of H2A.Z and H3 at HY5 in atino80. Genetic analysis revealed that AtINO80 acts in a phytochrome B- and HY5-dependent manner in the regulation of photomorphogenesis. Together, our study elucidates a mechanism wherein AtINO80 modulates nucleosome density and H2A.Z incorporation and represses the transcription of light-related genes, such as HY5, to fine tune plant photomorphogenesis.

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《Proceedings of the National Academy of Sciences of the United States of America.》 |2020年第52期|33679-33688|共10页
作者
Yang Chuanwei; Yin Liufan; Xie FaminMa MengmengHuang ShaZeng YueShen Wen-HuiDong AiwuLi Lin;
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作者单位

Sch Life Sci,Fudan Univ;

State Key Lab Genet Engn,Sch Life Sci,Fudan Univ;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种英语
中图分类自然科学总论;
关键词
AtINO80; photomorphogenesis; nucleosome; H2A.Z; transcription; TRANSCRIPTION FACTOR HY5; HISTONE DEACETYLASE HDA15; HOMOLOGOUS RECOMBINATION; PROTEIN; INO80; EXPRESSION; COP1; PHOSPHORYLATION; IDENTIFICATION; DEGRADATION;

AtINO80 represses photomorphogenesis by modulating nucleosome density and H2A.Z incorporation in light-related genes

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