Molecular Determinants of Peritoneal Dissemination in Gastric Adenocarcinoma

ValentinaMari; ValentinaAngerilli; GiadaMunariMarcoScarpaQuoc RiccardoBaoSalvatorePucciarelliMatteoFassanGayaSpolverato

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Molecular Determinants of Peritoneal Dissemination in Gastric Adenocarcinoma

机译：Molecular Determinants of Peritoneal Dissemination in Gastric Adenocarcinoma

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Background: Peritoneal dissemination represents a poor prognostic indicator in gastric cancer. Despite a comprehensive molecular characterization of this disease, no peritoneal dissemination-specific signature has been identified, limiting the tailoring of the surgical and oncological treatments. In this review, we outline the available literature focusing on the role of the different molecular pathways involved in the acquisition of peritoneal metastatic dissemination. Summary: According to our results, several molecular determinants are associated with peritoneal carcinomatosis and are involved in several cellular and molecular carcinogenetic processes. However, a comprehensive understanding of the complex molecular landscape of gastric carcinosis is still lacking. Key Messages: More efforts should be made toward the integration of molecular and histologic data to perform a risk prediction assessment of peritoneal dissemination based on molecular profiling and histological evaluation.

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《Digestive diseases》 |2023年第1期|49-65|共17页
作者
ValentinaMari; ValentinaAngerilli; GiadaMunariMarcoScarpaQuoc RiccardoBaoSalvatorePucciarelliMatteoFassanGayaSpolverato;
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作者单位

Department of Surgical, General Surgery 3, Oncological and Gastroenterological Sciences (DISCOG),;

Surgical Pathology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy;

Veneto Institute of Oncology (I.O.V. IRCSS), Padua, Italy;

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正文语种英语
中图分类消化系及腹部疾病;
关键词
Gastric adenocarcinoma; Biomarkers; Peritoneal dissemination; Molecular signatures;

Molecular Determinants of Peritoneal Dissemination in Gastric Adenocarcinoma

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