Reproductive Toxicity and Teratogenicity of Fluorene-9-bisphenol on Chinese Medaka {Oryzias sinensis): A Study from Laboratory to Field

Xiaolin Fan; Jilong Guo; Xiaojing Jia

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Reproductive Toxicity and Teratogenicity of Fluorene-9-bisphenol on Chinese Medaka {Oryzias sinensis): A Study from Laboratory to Field

机译：Reproductive Toxicity and Teratogenicity of Fluorene-9-bisphenol on Chinese Medaka {Oryzias sinensis): A Study from Laboratory to Field

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摘要

Fluorene-9-bisphenol (BHPF), a bisphenol A (BPA) substitute, has been increasingly used as a material in syntheses of polymers that are widely used in road markings, artificial tracks, coating floors, building paints, etc., increasing the likelihood of BHPF contamination in the aquatic environment due to its release from the products. However, to date, it is unknown whether it may have actual impacts on fish in real environments. In this study, a 105-day exposure experiment of BHPF at various concentrations (0.01, 0.1, 1, and 10 //g/ L) on Chinese medaka (Oryzias sinensis) was performed under laboratory conditions and found decreased fecundity, such as lower egg qualities and quantities, retarded oogenesis, and atretic follicles in the fish and deformed eyes and bodies in its FI generation. Toxico-transcriptome analyses showed that estrogen-responsive genes were significantly suppressed by BHPF, indicating that antagonist properties of BHPF on estrogen receptors might be causes for the decreased fecundity. Field investigations (Beijing) demonstrated that BHPF was detectable in 60 surface waters, with a mean concentration of 10.49 ± 6.33 ng/L, by gas chromatography—mass spectrometry, and similar effects in wild Chinese medaka were also observed, some of which the parameters were found to be obviously correlated with the BHPF levels in corresponding waters.

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来源
《Environmental Science & Technology: ES&T》 |2023年第1期|561-569|共9页
作者
Xiaolin Fan; Jilong Guo; Xiaojing Jia;
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作者单位

College of Urban and Environmental Sciences, MOE Laboratory for Earth Surface Process, Peking University, Beijing 100871, China;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类环境科学、安全科学;
关键词
fluorene-9-bisphenol; Chinese medaka; antiestrogenicity; reproductive toxicity; teratogenicity; eye malformations;

Reproductive Toxicity and Teratogenicity of Fluorene-9-bisphenol on Chinese Medaka {Oryzias sinensis): A Study from Laboratory to Field

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