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Altered brain connectivity during visual stimulation in schizophrenia

机译：Altered brain connectivity during visual stimulation in schizophrenia

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Abstract Schizophrenia (SCZ) can be described as a functional dysconnectivity syndrome that affects brain connectivity and circuitry. However, little is known about how sensory stimulation modulates network parameters in schizophrenia, such as their small-worldness (SW) during visual processing. To address this question, we applied graph theory algorithms to multi-electrode EEG recordings obtained during visual stimulation with a checkerboard pattern-reversal stimulus. Twenty-six volunteers participated in the study, 13 diagnosed with schizophrenia (SCZ; mean age?=?38.3?years; SD?=?9.61?years) and 13 healthy controls (HC; mean age?=?28.92?years; SD?=?12.92?years). The visually evoked potential (VEP) showed a global amplitude decrease (p??0.05). As a signature of functional connectivity, graph measures were obtained from the Magnitude-Squared Coherence between signals from pairs of occipital electrodes, separately for the alpha (8–13?Hz) and low-gamma (36–55?Hz) bands. For the alpha band, there was a significant effect of the visual stimulus on all measures (p??0.05). For the low-gamma spectrum, both groups showed a decrease of Characteristic Path Length (L) during visual stimulation (p??0.05). This indicates dysconnectivity of the functional network in the low-gamma band of SCZ during stimulation, which might indirectly reflect an altered ability to react to new sensory input in patients. These results provide novel evidence about a possible electrophysiological signature of the global deficits revealed by the application of graph theory onto electroencephalography in schizophrenia.

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