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机译:Assessment of enzyme active site positioning and tests of catalytic mechanisms through X-ray-derived conformational ensembles
Dept Biochem,Stanford Univ;
Dept Bioengn & Therapeut Sci,Univ Calif San Francisco;
Stanford Synchrotron Radiat Lightsource,SLAC Natl Accelerator LabDept Chem,Stanford Univ;
enzyme catalysis; catalytic proposals; conformational ensembles; X-ray crystallography; ketosteroid isomerase; NUCLEAR-MAGNETIC-RESONANCE; BARRIER HYDROGEN-BONDS; KETOSTEROID ISOMERASE; GENERAL BASE; DELTA(5)-3-KETOSTEROID ISOMERASE; CRYSTAL-STRUCTURES; PROTEIN DYNAMICS; BINDING-ENERGY; TRANSITION; TEMPERATURE;