Neoadjuvant and adjuvant therapy for local excision of rectal cancer

Yael Feferman; Julio Garcia-Aguilar

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Neoadjuvant and adjuvant therapy for local excision of rectal cancer

机译：Neoadjuvant and adjuvant therapy for local excision of rectal cancer

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Local excision (LE) for early-stage rectal cancer is an attractive option compared to total mesorectal excision (TME), as it avoids many of the significant comorbidities and adverse functional outcomes associated with TME. However, LE for tumors with high-risk histopathologic features can lead to unacceptably high rates of local and distant recurrence. Neoadjuvant or adjuvant chemoradiotherapy can mitigate those risks in certain clinical settings and may expand the number of patients who can be safely treated with an organ-preserving approach. In this chapter, we will explore the available date supporting the use of neoadjuvant and adjuvant chemoradiation (CRT) for the treatment of high-risk early-stage rectal cancer and will discuss future studies that aim to answer some of the ongoing clinical questions related to this practice.

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来源
《Seminars in colon and rectal surgery》 |2022年第3期|100900-100900|共1页
作者
Yael Feferman; Julio Garcia-Aguilar;
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作者单位

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA;

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原文格式 PDF
正文语种英语
中图分类腹部外科学;
关键词
Rectal cancer; Neoadjuvant chemoradiotherapy; Local excision; Organ preservation; Total mesorectal excision;

Neoadjuvant and adjuvant therapy for local excision of rectal cancer

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