9,19-Cycloartenol glycoside G3 from Cimicifuga simplex regulates immune responses by modulating Th17/Treg ratio

Yang Su; Lun Wu; Guangrui MuQiuhong WangBingyou YangGenhong ChengHaixue Kuang

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9,19-Cycloartenol glycoside G3 from Cimicifuga simplex regulates immune responses by modulating Th17/Treg ratio

机译：9,19-Cycloartenol glycoside G3 from Cimicifuga simplex regulates immune responses by modulating Th17/Treg ratio

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Graphical abstract Display Omitted Abstract Cimicifuga simplex is a medicinal herb which has a wide range of biological activities. We isolated seven 9,19-cycloartenol glycosides from the roots of C. simplex , and among the glycosides, G3 exhibited the strongest inhibitory effect on immune responses, including suppressing the differentiation of CD 4+ T cells and directly suppressing the cytokine-induced JAK/STAT signaling pathways. In the IL-23-induced mouse ear model of skin disease, G3 repressed disease development by inhibiting the expression of pro-inflammatory mediators in murine ear skin. Moreover, G3 affected the maturation of DCs in vitro , thereby inducing T cell differentiation, resulting in an increased Treg phenotype and decreased Th17 phenotype. This study provides new evidence that G3 might ameliorate chronic inflammatory skin diseases by suppressing pathogenic CD 4+ T cell differentiation and the IL-17 + RORγt + /IL-10 + FoxP3 + ratio. These findings suggest that G3 might mediate the therapeutic effects observed in psoriasis patients following treatment with C. simplex . >

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来源
《Bioorganic and medicinal chemistry》 |2017年第17期|4917-4923|共7页
作者
Yang Su; Lun Wu; Guangrui MuQiuhong WangBingyou YangGenhong ChengHaixue Kuang;
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作者单位

Department of Microbiology, Immunology & Molecular Genetics, University of California Los Angeles;

Key Laboratory of Chinese Material Medica, Department of Pharmacology, Heilongjiang University of;

Graduate School of Heilongjiang, University of Chinese Medicine, Heilongjiang University of ChineseSchool of Traditional Chinese Medicine, Guangdong Pharmaceutical University;

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正文语种英语
中图分类药学;
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Cimicifuga simplex; 9; 19-Cycloartenol glycosides; IL-17+RORγt+/IL-10+FoxP3+ ratio; JAK/STAT pathways;

9,19-Cycloartenol glycoside G3 from Cimicifuga simplex regulates immune responses by modulating Th17/Treg ratio

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