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外文期刊>Clinical and experimental allergy :
>Inhibition of bronchial hyperresponsiveness to histamine induced by intravenous administration of leukotriene C4by novel thromboxane A2receptor antagonists ONO‐NT‐126 and ONO‐8809 in guinea‐pigs
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Inhibition of bronchial hyperresponsiveness to histamine induced by intravenous administration of leukotriene C4by novel thromboxane A2receptor antagonists ONO‐NT‐126 and ONO‐8809 in guinea‐pigs
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机译：Inhibition of bronchial hyperresponsiveness to histamine induced by intravenous administration of leukotriene C4by novel thromboxane A2receptor antagonists ONO‐NT‐126 and ONO‐8809 in guinea‐pigs
SummaryWe studied the effect of intravenous administration of leukotriene (LT) C4on bronchial responsiveness to histamine and airway wall thickening in guinea‐pigs. Guinea‐pigs were killed and the lungs were fixed in formalin. Slides from paraffin‐embedded sections of the lungs were stained and the airways that were cut in transverse sections were measured by tracing enlarged images using a digitizer. Moreover, airway resistance (Raw) was determined by a pulmonary mechanics analyser and we calculated two incides, an index of airway wall thickening and the one of airway hyperresponsiveness to histamine, from changes of baseline‐Raw and peak‐Raw following intravenous administration of histamine before and after the intravenous administration of LTC4. Intravenous administration of 3 μg/kg LTC4for 1 hr induced an increase of the relative thickness of the airway wall in peripheral bronchi by the histological examination. In analysis of airway function, intravenous administration of 3 μg/kg LTC4for 1 hr induced airway hyperresponsiveness to histamine with airway wall thickening. Thromboxane A2receptor antagonists ONO‐NT‐126 and ONO‐8809 inhibited the LTC4‐induced airway hyperresponsiveness to histamine in a dose‐dependent manner, but not the airway wall thickening induced by LTC4, suggesting that the effect of LTC4on bronchial hyperresponsiveness is likely to be
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