• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental Science & Technology: ES&T >Levels and Toxicokinetic Behaviors of PCDD,PCDF,and Coplanar PCB Congeners in Common Cormorants from Lake Biwa,Japan
【24h】

Levels and Toxicokinetic Behaviors of PCDD,PCDF,and Coplanar PCB Congeners in Common Cormorants from Lake Biwa,Japan

机译：Levels and Toxicokinetic Behaviors of PCDD,PCDF,and Coplanar PCB Congeners in Common Cormorants from Lake Biwa,Japan

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相关主题

摘要

Concentrations of polychlorinated dibenzo-p-dioxins(PCDDs),polychlorinated dibenzofurans(PCDFs),and coplanar polychlorinated biphenyls(Co-PCBs)were determined in the liver and pectoral muscle of common cormorants(Phalacrocoraxcarbo)collected from Lake Biwa,Japan.To clarify the toxicokinetic behaviors and potential toxicities of these chemicals,the present study addresses life-stage-and tissue-specific accumulation of the congeners.Total 2,3,7,8-tetrachlorodibenzo-p-dioxin toxic equivalents(TEQs)were in the range of 360 to 50 000 pg/g lipid weight in the liver and 310 to 12 000 pg/g lipid weight in the pectoral muscle.Among congeners,for which toxic equivalency factors were assigned,PCB126,2,3,4,7,8-P_5-CDF,and 1,2,3,7,8-P_5CDD made a greater contribution to total TEQs in the liver.Hepatic concentrations of T_4-to H_6-CDDs,P_5-and H_6CDFs,and Co-PCBs(except PCB77)significantly increased with growth of cormorants,leading to life-stage-related compositional changes.The concentration ratios of liverto pectoral muscle revealed preferential accumulation of higher chlorinated congeners in hepatic tissue.For most congeners,concentration ratios significantly increased with an increase in hepatic total TEQs,suggesting their concentration-dependent hepatic sequestration.These results imply the presence of hepatic binding protein(s)such as cytochrome P450,inducible by these chemicals,which mayfunction as a binding species different from aryl hydrocarbon receptor.On the basis of these results,we conclude that the toxicokinetic behavior of each congener is life-stage-,tissue-,and concentration-dependent.TEQs in wildlife populations exposed to multiple congeners with varying concentrations should be used with caution for risk assessment,even within a species.

著录项

获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号