ABSTRACTThe present status of support systems and devices for the injured liver is reviewed with emphasis on both long‐term and short‐term substitution. Longterm replacement can only be possible by the grafting or transplantation of a human and/or other primate liver. Most artificial systems may be applied for short‐term biological and technical substitution, e.g., by hemodialysis/hemoperfusion through adsorbents and resins. More sophisticated devices for detoxification of blood or cell‐free plasma in acute liver failure should combine the catalytic specificity of immobilized microsomal enzymes with the adsorptive capacity of activated charcoal, resins and affini
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