Baseline Widal Titer Among Healthy Adult Males from the Greater Mymensingh Division of Bangladesh

Arifuzzaman Khan; Fahim Ashher; Fahmida KhanamMohammad Marufur RahmanMomen KhanShyamal Kumar PaulMohammad Akram Hossain

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Baseline Widal Titer Among Healthy Adult Males from the Greater Mymensingh Division of Bangladesh

机译：Baseline Widal Titer Among Healthy Adult Males from the Greater Mymensingh Division of Bangladesh

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Background: Widal test is the most widely used laboratory investigationfor diagnosis of typhoid. However, the test interpretation remains controversial in thecontext of endemic regions such as Bangladesh, as agglutination occurs at varied titrationsamong a large percentage of healthy population. Paired Widal tests are oftennot feasible; hence single unpaired test has to be used for screening, diagnosis andtreatment.Objective: We aimed to assess the normal range of baseline titre for Anti TO, TH,AO, AH, BO agglutinins among healthy population in an endemic country with aview to guide the researchers and the clinicians, facilitating further investigation onupdating cut off points of single Widal test for screening and diagnosis of typhoidfever in the context of Bangladesh.Methods: A cross-sectional study was carried out in Mymensingh Medical College,Bangladesh on 2925 male immigration applicants. A single blood sample was collectedfor Widal test and interpreted using standard guidelines.Results: The highest baseline titer for Anti TO, TH, AO, AH, BO agglutinins among95 of the healthy participants was found to be 1:80 for each respectively. A titre of1: 40 was observed for BH antigen.Conclusion: In case of singular Widal test, baseline values for the normal rangewas found to be 1:20 - 1:80 for all the antigens (TO, TH, AO, AH, BO, BH), exceptBH, for which it was 1:20-1:40. Further studies, inclusive of other sociodemographicgroups and positive controls are required to determine the updatedcut off values.

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《Infectious disorders drug targets》 |2018年第3期|233-240|共8页
作者
Arifuzzaman Khan; Fahim Ashher; Fahmida KhanamMohammad Marufur RahmanMomen KhanShyamal Kumar PaulMohammad Akram Hossain;
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作者单位

CSF Global, Dhaka, Bangladesh;

National Institute of Preventive and Social Medicine (NIPSOM), Dhaka, Bangladesh;

Center for Medical Biotechnology, MIS, DGHS, BangladeshDepartment of Microbiology Mymensingh Medical College, Mymensingh, Bangladesh;

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正文语种英语
中图分类药学;
关键词
Widal test; Typhoid fever; Paratyphoid fever; Screening test; Endemic regions; Artigens;

Baseline Widal Titer Among Healthy Adult Males from the Greater Mymensingh Division of Bangladesh

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