Cellular expression of GDNF mRNA suggests  multiple functions inside and outside the nervous system

Christopher A.Nosrat; AndreasTomac; EvaLindqvistSvenLindskogChristianHumpelIngridStrömbergTedEbendalBarry J.HofferLarsOlson

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Cellular expression of GDNF mRNA suggests multiple functions inside and outside the nervous system

机译：Cellular expression of GDNF mRNA suggests multiple functions inside and outside the nervous system

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Glial-cell-line-derived neurotrophic factor (GDNF) is a distant member of the transforming growth factor-β family and has potent neurotrophic effects on several classes of neurons including dopamine neurons and motoneurons. Here, we have used in situ hybridization to describe the development of the cellular expression of GDNF mRNA pre- and postnatally. Consistent with dopaminotrophic activity, GDNF mRNA is expressed in the developing basal ganglia and the olfactory tubercle. It is also found in a thalamic nucleus, in neurons of the substantia innominata, in the developing Purkinje neurons and the developing locus coeruleus area, and in trigeminal brainstem nuclei. In the spinal cord, neuronal expression is found in Clarke’s column. GDNF mRNA is also expressed in the dorsal horns during development. Additional GDNF mRNA expression in the head region includes the carotid body, the retina, the vibrissae, the inner ear, the ear canal, and epithelium in the nasal cavity. Prominent expression is also found in the developing teeth. The widespread expression of GDNF in developing skeletal muscle is consistent with trophic activity on α-motoneurons. The smooth muscle layers of the gastrointestinal tract are also strongly positive. A very strong signal is found in the outer mesenchyme of the developing metanephric kidney. We conclude that GDNF mRNA is expressed in many different cellular systems inside and outside the central nervous system during development, suggesting multiple functions of GDNF in the developing organ

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《cell and tissue research》 |1996年第2期|191-207|共页
作者
Christopher A.Nosrat; AndreasTomac; EvaLindqvistSvenLindskogChristianHumpelIngridStrömbergTedEbendalBarry J.HofferLarsOlson;
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Department of Neuroscience, Karolinska Institute, S-17177 Stockholm, Sweden;

Department of Oral Diagnostics, Divsion of Oral Pathology, Karolinska Institute, Huddinge Hospital, S-14104 Huddinge, Sweden;

Neurochemistry Unit, Department of Psychiatry, University of Innsbruck, A-6020 Innsbruck, AustriaDepartment of Developmental Neuroscience, Biomedical Center, Uppsala University, S-75123 Uppsala, SwedenDepartment of Pharmacology, University of Colorado Health Sciences Center, Denver, CO 80262, USA;

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Cellular expression of GDNF mRNA suggests multiple functions inside and outside the nervous system

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