Glucocorticoid receptor levels of myeloma cells were quantitated in 7 patients with multiple myeloma. In 4 patients, glucocorticoid receptor levels were less than 10 fmol/106cells. In 3 patients, receptor levels were from 17.6 to 21.4 fmol/106cells. We further examined the correlation between glucocorticoid receptor levels and effect of dexamethasone on14C‐thymidine incorporation and cell viability using 2 myeloma cell lines, OPM‐1 and OPM‐2, established from a patient with multiple myeloma. Glucocorticoid receptor levels of OPM‐1 and OPM‐2 were 8.5 fmol/106cells and 63.2 fmol/106cells, respectively. The sensitivity of OPM‐1 to dexamethasone in these studies was lower than that of OPM‐2. These results suggest the possibility that the low level of glucocorticoid receptor in myeloma cells may be important for predicting a poor response to glucocort
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