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>Regulation of melanin synthesis in mammalian cells, as studied by somatic hybridization. I. Evidence for negative control
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Regulation of melanin synthesis in mammalian cells, as studied by somatic hybridization. I. Evidence for negative control
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机译：Regulation of melanin synthesis in mammalian cells, as studied by somatic hybridization. I. Evidence for negative control
AbstractSomatic hybrids between pigmented Syrian hamster cells and unpigmented mouse cells were isolated and propagatedin vitro. These hybrids are unpigmented and lack dopa oxidase (and tyrosinase) activity, which is correlated with the pigmentation of the Syrian hamster cells. In contrast, the presence of three other enzymes (LDH, MDH, and thymidine kinase) also specified by the hamster genome but unrelated to pigment synthesis is observed in the hybrid cells. This suggests that the repression of dopa oxidase in these cells is a specific effect on the enzyme associated with the differentiated state of pigment cells. It is concluded that the genetic control of differentiation in this case involves a diffusible regulator substance which functions negatively.
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