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首页> 外文期刊>Catalysis Letters >Hydrogenation of 5-Alkylidene-2,4-Thiazolidiones on Pd/C Catalysts Under Mild Conditions: An Alternative Synthesis Route to Pioglitazone
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Hydrogenation of 5-Alkylidene-2,4-Thiazolidiones on Pd/C Catalysts Under Mild Conditions: An Alternative Synthesis Route to Pioglitazone

机译：Hydrogenation of 5-Alkylidene-2,4-Thiazolidiones on Pd/C Catalysts Under Mild Conditions: An Alternative Synthesis Route to Pioglitazone

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The hydrogenation of 5-alkylidene-2,4-thiazo-lidiones was studied using Pd/C to establish an alternative process for pioglitazone synthesis. The reportedly sluggish reactivity was due to the high reaction temperature in formic acid. The conditions were improved to 1 atm at 296 K, which results in a quantitative product with a smaller amount of the catalyst.

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