Mechanisms and functions of DNA mismatch repair.

Li GM

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Mechanisms and functions of DNA mismatch repair.

机译：Mechanisms and functions of DNA mismatch repair.

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DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. The specificity of MMR is primarily for base-base mismatches and insertion/deletion mispairs generated during DNA replication and recombination. MMR also suppresses homeologous recombination and was recently shown to play a role in DNA damage signaling in eukaryotic cells. Escherichia coli MutS and MutL and their eukaryotic homologs, MutSalpha and MutLalpha, respectively, are key players in MMR-associated genome maintenance. Many other protein components that participate in various DNA metabolic pathways, such as PCNA and RPA, are also essential for MMR. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including hereditary non-polyposis colorectal cancer, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.

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来源
《Cell research》 |2008年第1期|85-98|共14页
作者
Li GM;
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作者单位

Graduate Center for Toxicology and Markey Cancer Center, Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY 40536, USA. gmli@email.uky.edu;

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收录信息美国《科学引文索引》(SCI);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类细胞生物学;
关键词
Animals; DNA; DNA Mismatch Repair; Humans; Metabolic Networks and Pathways; Models; Biological; Neoplasms; Signal Transduction/physiology;

Mechanisms and functions of DNA mismatch repair.

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