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Skin tests with tuberculin (PPD)Candida albicansand Trichophyton spp. in cryptogenic fibrosing alveolitis and asbestos related lung disease

机译:Skin tests with tuberculin (PPD)Candida albicansand Trichophyton spp. in cryptogenic fibrosing alveolitis and asbestos related lung disease

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SummaryDelayed skin hypersensitivity responses were elicited in patients with cryptogenic fibrosing alveolitis (CFA) (twenty‐eight), asbestosis (eight), mesothelioma (eight) and a ‘control’ group, having miscellaneous lung diseases not normally believed to be associated with T cell deficiency (twenty). Three antigens,Candida albicans, trichophyton and purified protein derivative (PPD) in a range of doses were used.There was no evidence of impaired cellular immunity in CFA or in mesothelioma, indeed there was a significantly increased frequency of reactions to PPD in both of these conditions (P<0.05 andP<0.01 respectively). There was, however, a trend of decreased responsiveness in the group with asbestosis.The dosage regimen used rarely gave completely negative results (only one of thirty‐two completed tests), and may provide a basis for a simple and standard regimen for screening patients suspected of having defective T cell re

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