首页>
外文期刊>british journal of haematology
>Interleukin‐2 induces activation of coagulation and fibrinolysis: resemblance to the changes seen during experimental endotoxaemia
【24h】
Interleukin‐2 induces activation of coagulation and fibrinolysis: resemblance to the changes seen during experimental endotoxaemia
展开▼
机译：Interleukin‐2 induces activation of coagulation and fibrinolysis: resemblance to the changes seen during experimental endotoxaemia
Summary.The administration of Interleukin‐2 (IL‐2) causes the release or generation of other cytokines such as tumour necrosis factor (TNF) which, by disturbing the anticoagulant properties of the endothelium, may induce a procoagulant state in patients receiving this drug.We therefore evaluated the effects of IL‐2 on coagulation and fibrinolysis in 14 patients receiving 12 or 18 × 106IU/m2/d of IL‐2 given as a 15 min infusion for 5 d. Blood samples were drawn at short intervals after the first IL‐2 infusion. The parameters were analysed by way of analysis for repeated measures (F tests rather thanttests).During the first day, thrombin‐antithrombin (TAT) complexes started to increase 2 h after the IL‐2 infusion, reaching peak levels at 4 h (n= 14; 11.2±6.4 μg/lv49.8±49.2 μg/l,P<0.01). Plasmin α2 antiplasmin (PAP) complexes showed a similar pattern rising from a mean baseline value of 17.5±7.6 nmol/l to 66.48±47.7 nmol at 4 h (P<0.01). In four patients the peak of PAP preceeded that of TAT. Tissue plasminogen activator (tPA) rose from a mean baseline value of 4.9±3.7 μg/l to 26.3±13.5 μg/l at 4 h (P<0.01). Plasminogen‐activator‐inhibitor‐1 (PAI‐1) levels increased from 59.35 μg/l to 113.39 μg/l at 6 h (P<0.01). tPA PAI‐1 complexes increased from 0.15 ±0.07 to 0.69±0.21 nmol/l at 6 h (P<0.01).Our study indicates that IL‐2 activates the coagulation and fibrinolytic systemsin vivo.The changes resemble the perturbations observed after endotoxin/TNF administration. These abnormalities may play a role in
展开▼
