Synthesis and application of a novel, crystalline phosphoramidite monomer with thiol terminus, suitable for the synthesis of DNA conjugates.

Kupihar Z; Schmel Z; Kele ZPenke BKovacs L

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Synthesis and application of a novel, crystalline phosphoramidite monomer with thiol terminus, suitable for the synthesis of DNA conjugates.

机译：Synthesis and application of a novel, crystalline phosphoramidite monomer with thiol terminus, suitable for the synthesis of DNA conjugates.

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摘要

A new, crystalline 5'-thiol modifier phosphoramidite monomer (3), suitable for DNA synthesis, has been prepared. This monomer has been built into an oligonucleotide using the standard protocol. After cleavage, purification and removal of the trityl group with Ag(+), a free 5'-thiol terminal oligonucleotide (15) has been obtained which was subsequently coupled to a cysteine derivative via a disulfide bridge to afford conjugate 16.

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来源
《Bioorganic and medicinal chemistry》 |2001年第5期|1241-1247|共7页
作者
Kupihar Z; Schmel Z; Kele ZPenke BKovacs L;
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作者单位

Department of Medicinal Chemistry, Dom ter 8, University of Szeged, H-6720 Szeged, Hungary. kupi;

harsight.com;

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原文格式 PDF
正文语种英语
中图分类药学;生物化学;
关键词
Chromans; Cysteine; Disulfides; Oligonucleotides; Organophosphorus Compounds; 色满类; 半胱氨酸; 二硫化物类; 寡核苷酸类; 有机磷化合物; 戊酸类; 巯基化合物;

Synthesis and application of a novel, crystalline phosphoramidite monomer with thiol terminus, suitable for the synthesis of DNA conjugates.

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