Novel diterpenes with cytotoxic, anti-malarial and anti-tuberculosis activities from a brown alga Dictyota sp.

Jongaramruong J; Kongkam N

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Novel diterpenes with cytotoxic, anti-malarial and anti-tuberculosis activities from a brown alga Dictyota sp.

机译：Novel diterpenes with cytotoxic, anti-malarial and anti-tuberculosis activities from a brown alga Dictyota sp.

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摘要

Two new diterpenes, (1E,2R*,3R*,4S*,6E,18S*)-4,18-dihydroxydictyolactone (1) and 8alpha,11-dihydroxypachydictyol A (2), together with fucoxanthin (3) and a known diterpene 4alpha-hydroxycrenulatane (4) were isolated from the methanol extract of the brown alga Dictyota sp. collected from Bangsaen Beach, Thailand. Their structures were determined by spectroscopic data. The relative stereochemistry of 1 was established by NOE difference and NOESY experiments. Compound 1 showed weak anti-tuberculosis activity while 2 displayed strong cytotoxicity against the NCI-H187 cell line, and potent anti-malarial activity. In addition, 3 was active against HSV-1 and malarial parasites.

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来源
《Journal of Asian natural products research》 |2007年第8期|743-751|共9页
作者
Jongaramruong J; Kongkam N;
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作者单位

Department of Chemistry, Faculty of Science, Burapha University, Bangsaen, Chonburi, Thailand. jongkoln@buu.ac.th;

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正文语种英语
中图分类药学;
关键词
Diterpenes; Laminaria japonica; brown; Tuberculosis; Stereochemistry; 二萜类; 结核;

Novel diterpenes with cytotoxic, anti-malarial and anti-tuberculosis activities from a brown alga Dictyota sp.

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