Indole alkaloid glucosides from the roots of Isatis indigotica

Liu Yu-Feng; Chen Ming-Hua; Lin ShengLi Yu-HuanZhang DanJiang Jian-DongShi Jian-Gong

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Indole alkaloid glucosides from the roots of Isatis indigotica

机译：Indole alkaloid glucosides from the roots of Isatis indigotica

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摘要

Five new indole alkaloid glucosides named isatindigotindolosides A-E (1-5), along with three known analogs (6-8), were isolated from an aqueous extract of the Isatis indigotica roots. Their structures including the absolute configurations were determined based on comprehensive spectroscopic data analysis, combined with chemical methods and electronic circular dichroism spectra calculations. In the preliminary assays, compounds 1, 6 and 7 showed antiviral activity against influenza virus A/Hanfang/359/95 (H3N2) with IC50 values of 14.6-33.3 mu M. Compound 1 also exhibited inhibitory effect against nitric oxide (NO) production in microglial cell BV2 with an inhibition ratio of 93.0 at 10 mu M.

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来源
《Journal of Asian natural products research》 |2016年第2期|1-12|共12页
作者
Liu Yu-Feng; Chen Ming-Hua; Lin ShengLi Yu-HuanZhang DanJiang Jian-DongShi Jian-Gong;
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作者单位

Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Substance & Funct Nat Med, Beijing 100050;

Peking Union Med Coll, Beijing 100050, Peoples R China;

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原文格式 PDF
正文语种英语
中图分类药学;
关键词
Isatis indigotica; antiviral activity; indole alkaloid glucoside; isatindigotindolosides A-E; Cruciferae; inhibition activity against nitric oxide production;

Indole alkaloid glucosides from the roots of Isatis indigotica

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