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首页> 外文期刊>journal of cellular physiology >Stimulation of hepatocyte DNA synthesis by prostaglandin E2and prostaglandin F2α additivity with the effect of norepinephrine, and synergism with epidermal growth factor
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Stimulation of hepatocyte DNA synthesis by prostaglandin E2and prostaglandin F2α additivity with the effect of norepinephrine, and synergism with epidermal growth factor

机译：Stimulation of hepatocyte DNA synthesis by prostaglandin E2and prostaglandin F2α additivity with the effect of norepinephrine, and synergism with epidermal growth factor

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AbstractPrevious data obtained in vivo and in vitro suggest that both prostaglandins (PGs) and catecholamines may have a role in promoting hepatocyte proliferation, and PGE2and PGFF2αhave also been implicated as mediators of the mitogenic actions of epidermal growth factor (EGF) (and transforming growth factor alpha TGFα). We have studied the effects of PGs and norepinephrine on DNA synthesis in serum‐free primary cultures of rat hepatocytes, and compared the PG effects with those of norepinephrine. PGE2, PGF2α, PGD2, and the synthetic analog dimethyl‐PGE2markedly enhanced the DNA synthesis. A more quantitative analysis of the effects of PGE2and PGF2αon the DNA synthesis, in the presence and absence of EGF, indicated that these PGs interacted in an essentially multiplicative manner with the effect of EGF. The effects of PGE2and PGF2αshowed almost complete additivity with the stimulation of DNA synthesis produced by maximally effective concentrations of norepinephrine. The data suggest (a) that PGE2and PGF2αfacilitate and synergize with, rather than mediate, the actions of EGF in hepatocytes, and (b) that this effect of the PGs occurs by mechanisms that are at least partly distinct from those of norepinephrine. © 1994 wiley

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