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外文期刊>european journal of haematology
>Allo‐activated CD4+ and CD8+ lymphocyte subsets: New ultrastructural findings based on computer‐assisted image analysis
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Allo‐activated CD4+ and CD8+ lymphocyte subsets: New ultrastructural findings based on computer‐assisted image analysis
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机译：Allo‐activated CD4+ and CD8+ lymphocyte subsets: New ultrastructural findings based on computer‐assisted image analysis
Abstract:Primary allo‐stimulation induces substantial and differentiated modifications in the development of cytoplasmic organelles of peripheral T‐lymphocyte subsets. The present computer‐assisted image analysis provides evidence that the CD4 + subset undergoes significant increase in organelle density after stimulation, while the CD8 + subset exhibits a post‐stimulation organelle development proportional to the cell size. Each immunological subset contains two distinct patterns of cytoplasmic organization, here defined as type I (containing a few cytoplasmic organelles) and type II (with well‐developed synthesis and storage organelles). On the basis of these findings cytologic parameters could be ascribed to a heterogeneous proliferation of functionally distinct T‐cell clones in CD4 + and CD
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